Perturbation type | Gene | Citation | Cancer type | Gene-disease relation |
---|---|---|---|---|
Top gains | GRAMD2B (Isoform switch) (GRAMD3) | GDS1732 (GEO Profiles) (not yet published) | THCA | Differentially expressed in THCA patients compared to expression profiles in heathy controls |
Top gains | GRAMD1C (Isoform switch) | GDS1732 (GEO Profiles) (not yet published) | THCA | Differentially expressed in THCA patients compared to expression profiles in heathy controls |
Top losses | ANKS1B (Isoform switch) | GDS1732 (GEO Profiles) (not yet published) | THCA | Differentially expressed in THCA patients compared to expression profiles in heathy controls |
Top losses | ERBB4 (Isoform switch) | 8640794 | THCA | Coexisting overexpression of epidermal growth factor receptor; c-erbB-2; c-erbB-3; and c-erbB-4 was demonstrated in 36 (64%) of 56 papillary thyroid carcinomas |
Top cancer-specific gains | ALK | 25501013 | THCA | Pathogenic ALK translocations are associated with papillary thyroid carcinoma. |
Top cancer-specific gains | HIPK4 | 18575725 | THCA | Differentially expressed in tumor samples compared to normal samples. |
Top cancer-specific gains | RAB40A | 24423316 | THCA | Differentially expressed in tumor samples compared to normal samples. |
Top cancer-specific gains | PDZK1 | 18575725 | THCA | Differentially expressed in tumor samples compared to normal samples. |
Top cancer-specific gains | RAB40A | 18575725 | THCA | Differentially expressed in tumor samples compared to normal samples. |
Top losses | VEGFD | 17573672 | THCA | Analysis of micro‐dissected samples of the tumor and of the paired normal thyroid tissue revealed that RNA transcripts for VEGF‐D were significantly less numerous in the tumor tissue. |
Top cancer-specific losses | CSAG1 | 24423316 | THCA | Differentially expressed in tumor samples compared to normal samples. |
SMGs within edgetic gains or losses | AKT1 | 21898122 | THCA | The expression of AKT1 was five to ten times higher than in benign samples. |
PRKAR1A | 22514108 | THCA | The loss of Prkar1a in the thyroid glands leads to thyroid hyperfunction and the formation of follicular thyroid cancer in mice. |
To download a file, either filter the gene of interest or select all the entries and then press the "Download as Excel table" button