Perturbation type | Gene | Citation | Cancer type | Gene-disease relation |
---|---|---|---|---|
Top gains | ANK1 (Isoform switch) | 22603795 | Barret esophagus | Differentially expressed in Barrett esopjhagus patients compared to expression profiles in heathy controls |
Top gains | TTN (Isoform switch) | 29101304 | ESCC | lncRNA-TTN-AS1 is significantly associated with overall survival and provides additional prognostic evidence for esophageal squamous cell carcinoma (ESCC) patients |
Top losses | CEP170B (Isoform switch) | 22603795 | Barret esophagus | Differentially expressed in Barrett esopjhagus patients compared to expression profiles in heathy controls |
Top gains | CLEC5A | 22603795; 21445269 | Barret esophagus; Gastric cancer | Differentially expressed in tumor samples. |
Top gains | HOXA9 | 21259057; 29113222 | Esophageal cancer; Gastric cancer | Differentially expressed in tumor samples. |
Top gains | MAPK15 | 30957200; 26035356 | ESCC; Gastric cancer | MAPK15 mutation associated with ESCC. : Overexpression of MAPK15 in gastric cancer is associated with copy number gain |
Top gains | STAC3 | 22603795; 21445269 | Barret esophagus; Gastric cancer | Differentially expressed in tumor samples. |
Top gains | TNFRSF9 | 28442363; 21684283 | ESCC; Gastric cancer | Dysregulated in ESCC. : Differentially expressed in gastric cancer. |
Top gains | TNFSF11 | 25019155; 29340518 | ESCC; Gastric cancer | RANKL(TNFSF11) rs9533156 T>C is associated with a risk of ESCC. : Rankl (TNFSF11) expression predicts poor prognosis in gastric cancer patients |
Top cancer-specific gains | STAC3 | 22603795; 21445269 | Barret esophagus; Gastric cancer | Differentially expressed in tumor samples. |
Top losses | ADCYAP1 | 17636545; 10850463 | Barret esophagus; Gastric cancer | Dysregulaed in Barrett's adenocarcinoma. : Overexpression of PACAP(ADCYAP1) receptors has been reported in stomach cancer. |
Top losses | AGTR1 | 27564102; 25224569 | ESCC; Gastric cancer | Angiotensin II/AT1R signaling stimulates ESCC growth; in part through mTOR activation. : The angiotensin II type 1 receptor blocker candesartan suppresses proliferation and fibrosis in gastric cancer. |
Top losses | APP | 15252842; 30686901 | ESCC; Gastric cancer | The majority of ESCCs also had increase in APP mRNA expression. : Amyloid-beta(APP) oligomerization is strongly associated with gastric mucosal atrophy. |
Top losses | ASB16 | 22603795; 22735568 | Barret esophagus; Gastric cancer | Differentially expressed in barret esophagus and gastric cancer samples. |
Top losses | BMX | 22603795; 25499959 | Barret esophagus; Gastric cancer | Differentially expressed in barret esophagus. : BMX-ARHGAP fusion transcript is differentially expressed in gastric cancer. |
Top losses | CAMK2B | 30956903; 25174603 | ESCC; Gastric cancer | Differentially expressed in esophageal cancer samples. : CaMKII promotes gastric cancer cell metastasis by NF‑kappaB and Akt‑mediated‑MMP‑9 production. |
Top losses | CCT6B | 20955586; 11782383 | ESCC; Gastric cancer | Differentially expressed in esophageal and gastric cancer samples . |
Top losses | EID3 | 22603795; 22735568 | Barret esophagus; Gastric cancer | Differentially expressed in barret esophagus and gastric cancer samples. |
Top losses | ENPP6 | 23341893; 30948703 | ESCC; Gastric cancer | Differentially expressed in esophageal and gastric cancer samples. |
Top losses | ESR2 | 23358850; 26503819 | ESCC; Gastric cancer | ESR2 SNPs associated with ESCC and gastric cancer. |
Top losses | GPM6A | 20955586; 15875780 | ESCC; Gastric cancer | Differentially expressed in esophageal and gastric cancer samples. |
Top losses | HSPA1L | 17318615; 11782383 | ESCC; Gastric cancer | Differentially expressed in esophageal and gastric cancer samples. |
Top losses | PACRG | 22603795; 22735568 | Barret esophagus; Gastric cancer | Differentially expressed in barret esophagus and gastric cancer samples. |
Top losses | RXRG | 29600044; 22901127 | ESCC; Gastric cancer | Differentially expressed in esophageal and gastric cancer samples. |
Top losses | INA | 22603795; 11782383 | Barret esophagus; Gastric cancer | Differentially expressed in barret esophagus and gastric cancer samples. |
Top losses | LURAP1 | 22603795; 22735568 | Barret esophagus; Gastric cancer | Differentially expressed in barret esophagus and gastric cancer samples. |
Top losses | SCN2B | 22603795; 22735568 | Barret esophagus; Gastric cancer | Differentially expressed in barret esophagus and gastric cancer samples. |
Top losses | SPIN2B | 20955586; 22735568 | ESCC; Gastric cancer | Differentially expressed in esophageal and gastric cancer samples. |
Top losses | TCEANC | 22603795; 22735568 | Barret esophagus; Gastric cancer | Differentially expressed in barret esophagus and gastric cancer samples. |
Top losses | TRIM46 | 22603795; 25731870 | Barret esophagus; Gastric cancer | Differentially expressed in barret esophagus cancer samples. : TRIM46 polymorphism associated with gastric cancer. |
Top losses | TRIM9 | 22603795; 11782383 | Barret esophagus; Gastric cancer | Differentially expressed in barret esophagus and gastric cancer samples. |
Top losses | TSSK3 | 22603795; 22735568 | Barret esophagus; Gastric cancer | Differentially expressed in barret esophagus and gastric cancer samples. |
Top losses | USHBP1 | 22603795; 22735568 | Barret esophagus; Gastric cancer | Differentially expressed in barret esophagus and gastric cancer samples. |
Top losses | SPATA24 | 22603795; 22735568 | Barret esophagus; Gastric cancer | Differentially expressed in barret esophagus and gastric cancer samples. |
Top losses | ZNF396 | 22603795; 22127425 | Barret esophagus; Gastric cancer | Differentially expressed in barret esophagus and gastric cancer samples. |
Top cancer-specific losses | HSPA1L | 17318615; 11782383 | ESCC; Gastric cancer | Differentially expressed in esophageal and gastric cancer samples. |
Top cancer-specific losses | TCEANC | 22603795; 22735568 | Barret esophagus; Gastric cancer | Differentially expressed in barret esophagus and gastric cancer samples. |
Top cancer-specific losses | SPIN2B | 20955586; 22735568 | ESCC; Gastric cancer | Differentially expressed in esophageal and gastric cancer samples. |
Top cancer-specific losses | EDA2R | 29796185; 22735568 | ESCC; Gastric cancer | Differentially expressed in esophageal and gastric cancer samples. |
Top cancer-specific losses | CCT6B | 22603795; 11782383 | Barret esophagus; Gastric cancer | Differentially expressed in barret esophagus and gastric cancer samples. |
Top cancer-specific losses | USP6 | 22603795 | Barret esophagus | Differentially expressed in barret esophagus samples. |
Top cancer-specific losses | ETFBKMT | 22603795; 15800983 | Barret esophagus; Gastric cancer | Differentially expressed in barret esophagus and gastric cancer samples. |
SMGs within edgetic gains or losses | ATR | 27839769; 28138034 | Esophageal cancer; Gastric cancer | ATR inhibitor demonstrates improved response to standard therapies for esophageal cancer. : An oral inhibitor of ATR induces synthetic lethality with ATM deficiency in gastric cancer cells. |
SMGs within edgetic gains or losses | CDH1 | 27600761; 9537325 | Esophageal cancer; Familial gastric cancer | Decreased expression of CDH1 in the cell membranes of cancer cells is associated with poor survival of patients with esophageal cancer.: Hereditary CDH1 mutation associated with gastric cancer. |
SMGs within edgetic gains or losses | ERBB3 | 29138285 | Esophageal cancer; Gastric cancer | Differentially expressed in esophageal and gastric cancer samples. |
SMGs within edgetic gains or losses | FAT3 | 25151357; 30005210 | ESCC; Gastric cancer | FAT3 mutation associated with ESCC. : MEF2C-AS1 or FENDRR down-regulation reduced FAT3; NTN1; LYVE1 gene expression and promoted aggressive tumor phenotypes. |
SMGs within edgetic gains or losses | GRIN2A | 17922030; 11782383 | ESCC; Gastric cancer | The NMDAR2A promoter was methylated in all esophageal squamous cell carcinoma. : Differentially expressed in gastric cancer samples. |
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