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Prominent proteins in cancer
This is the list of significantly mutated genes (SMGs) and other proteins significantly involved in edgetic perturbations in LIHC.
Perturbation typeGeneCitationCancer typeGene-disease relation
Top gainsKANK2 (Isoform switch)20200238LIHCDifferentially expressed in LIHC patients compared to expression profiles in heathy controls
Top gainsWDR83 (Isoform switch)20200238LIHCDifferentially expressed in LIHC patients compared to expression profiles in heathy controls
Top lossesHR (Isoform switch)20200238LIHCDifferentially expressed in LIHC patients compared to expression profiles in heathy controls
Top lossesRARB (Isoform switch)20200238LIHCDifferentially expressed in LIHC patients compared to expression profiles in heathy controls
Top lossesDDX11 (Isoform switch)28496001LIHCPotential therapy targets for human hepatocellular carcinoma.
Top lossesSLAMF7 (Isoform switch)20200238LIHCDifferentially expressed in LIHC patients compared to expression profiles in heathy controls
Top cancer-specific gainsEBF230089500LIHCDifferentially expressed in tumor samples compared to normal samples.
Top cancer-specific gainsZNF2321965783LIHCZNF23 mRNA levels increased in the HepG2 cells.
Top cancer-specific gainsWNT3A28902357LIHCExpression of Wnt3a was significantly increased in tumor tissues compared with normal liver tissues..
Top lossesAMHR225945129LIHCAMHR2 was hypermethylated and transcriptionally repressed LIHC as compared to cancer-free tissue.
Top cancer-specific lossesBMP10www.biorxiv.org/content/biorxiv/early/2018/06/08/342204.full.pdfLIHCBMP10 was down-regulated in tumor samples of all LIHC stages compared to the controls.

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