showme
Prominent proteins in cancer
This is the list of significantly mutated genes (SMGs) and other proteins significantly involved in edgetic perturbations in HNSC.
Perturbation typeGeneCitationCancer typeGene-disease relation
Top gainsKHDRBS1 (Isoform switch)27473117Tongue carcinomaSam68 (KHDRBS1) reduces cisplatin-induced apoptosis in tongue carcinoma
Top gainsDLG2 (Isoform switch)26949921Oropharyngeal squamous cell carcinomaDifferentially expressed in cancer tissue compared to normal controls.
Top lossesGOSR2 (Isoform switch)15170515HNSCDifferentially expressed in HNSC patients compared to expression profiles in heathy controls
Top lossesBCAN (Isoform switch)15170515HNSCDifferentially expressed in HNSC patients compared to expression profiles in heathy controls
Top specific gainsHOXC925860510HNSCCmiR-196a and HOXB9 are overexpressed; perhaps coordinately; as HNSCC develops and exert a pro-tumourigenic phenotype in HNSCC and OPM cells.
Top specific gainsFOXL216467079HNSCC HPV positiveDifferentially expressed in HNSCC HPV positive tumor samples compared to HNSCC HPV negative tumor samples.
Top cancer-specific gainsCEBPE16467079HNSCC HPV positiveDifferentially expressed in HNSCC HPV positive tumor samples compared to HNSCC HPV negative tumor samples.
Top lossesAPP15252842OSCCHighly expressed in OSCC.
Top lossesASB1416467079HNSCC HPV positiveDifferentially expressed in HNSCC HPV positive tumor samples compared to HNSCC HPV negative tumor samples.
Top lossesASGR116164832OSCCDown-regulated in metastasizing SCCs of the tongue
Top lossesAURKC16467079HNSCC HPV positiveDifferentially expressed in HNSCC HPV positive tumor samples compared to HNSCC HPV negative tumor samples.
Top lossesBMX16467079HNSCC HPV positiveDifferentially expressed in HNSCC HPV positive tumor samples compared to HNSCC HPV negative tumor samples.
Top lossesCDKL316467079HNSCC HPV positiveDifferentially expressed in HNSCC HPV positive tumor samples compared to HNSCC HPV negative tumor samples.
Top lossesFLT312536197HNSCCAntitumor effect of secreted Flt3-ligand can act at distant tumor sites in a murine model of head and neck cancer.
Top lossesGDF917390032HNSCCDifferentially expressed in well-differentiated SCC tumor samples compared to moderately-differentiated SCC tumor samples (HNSC mouse model).
Top lossesGLIPR1L230089500HNSCCDifferentially expressed in tumor samples compared to normal samples
Top lossesINCA130089500HNSCCDifferentially expressed in tumor samples compared to normal samples
Top lossesPCK116467079HNSCC HPV positiveDifferentially expressed in HNSCC HPV positive tumor samples compared to HNSCC HPV negative tumor samples.
Top lossesRXRG28823962OPSCCRXRG-methylation(+) significantly associated with better prognosis in HPV-associated OPSCC
Top lossesTSSK316467079HNSCC HPV positiveDifferentially expressed in HNSCC HPV positive tumor samples compared to HNSCC HPV negative tumor samples.
Top lossesTUBB124425785HNSCCPaclitaxel (targeting TUBB1) most potently inhibited the growth of HNSCC cell lines.
Top lossesUSP4916467079HNSCC HPV positiveDifferentially expressed in HNSCC HPV positive tumor samples compared to HNSCC HPV negative tumor samples.
Top lossesWNK416467079HNSCC HPV positiveDifferentially expressed in HNSCC HPV positive tumor samples compared to HNSCC HPV negative tumor samples.
Top lossesZNF39616467079HNSCC HPV positiveDifferentially expressed in HNSCC HPV positive tumor samples compared to HNSCC HPV negative tumor samples.
Top cancer-specific lossesWNK416467079HNSCC HPV positiveDifferentially expressed in HNSCC HPV positive tumor samples compared to HNSCC HPV negative tumor samples.
SMGs within edgetic gains or lossesAJUBA28126323HNSCCMutations of the LIM protein AJUBA mediate sensitivity of head and neck squamous cell carcinoma to treatment with cell-cycle inhibitors.
SMGs within edgetic gains or lossesCUL329306329HNSCCKEAP1-NRF2-CUL3 axis which is strongly associated with tumorigenesis and drug resistance in HNSCC.
SMGs within edgetic gains or lossesEP30023307074HNSCCEP300 is histone acetyltransferase that is mutated in 7% of HNSCC.
SMGs within edgetic gains or lossesFBXW726619011HNSCCFBXW7 mutations associated with HNSC.
SMGs within edgetic gains or lossesHLA-B16467079HNSCC HPV positiveDifferentially expressed in HNSCC HPV positive tumor samples compared to HNSCC HPV negative tumor samples.
SMGs within edgetic gains or lossesHUWE128794691HNSCCHUWE1 is a target of lncRNAs described as deregulated in HNSCC.
SMGs within edgetic gains or lossesTP5327166782HNSCCTP53 mutations are significantly associated with short survival time and tumor resistance to radiotherapy and chemotherapy in HNSCC patients

To download a file, either filter the gene of interest or select all the entries and then press the "Download as Excel table" button