Prominent proteins in cancer

Prominent proteins in cancer
This is the list of significantly mutated genes (SMGs) and other proteins significantly involved in edgetic perturbations in COAD.

Perturbation type	Gene	Citation	Cancer type	Gene-disease relation
Top gains	CCNO (Isoform switch)	16531451	Colon cancer	Differentially expressed in SW480: a primary tumor colon cancer cell line: to that in SW620: an isogenic metastatic colon cancer cell line.
Top gains	CDKN1A (Isoform switch)	22634755	Colon cancer	Variations near CDKN1A influences colorectal cancer risk
Top losses	FLT1 (Isoform switch)	23794399	Colon cancer	SNPs in FLT1 were associated with colon cancer survival
Top losses	SHC1 (Isoform switch)	16531451	Colon cancer	Differentially expressed in SW480; a primary tumor colon cancer cell line; to that in SW620; an isogenic metastatic colon cancer cell line.
Top gains	CST4	29636621	CRC	CST4 is a blood biomarker in gastrointestinal cancers.
Top gains	OT (OXT)	16531451	CC	Differentially expressed in in SW480; a primary tumor CC cell line; compared to SW620; an isogenic metastatic CC cell line.
Top gains	KLC3	22399497	CRC	Differentially expressed in colorectal cancer tumors compared to adjacent non-cancerous tissues.
Top gains	MAPK15	20395206	CRC	The interaction between ERK8(MAP15) and c-Jun seems to increase the tumorigenic properties of HCT15 colorectal cancer cells.
Top cancer-specific gains	CITED1	23935526	CRC	Cited1 deficiency suppresses intestinal tumorigenesis.
Top losses	APP	11279603	CC	Amyloid beta protein precursor is involved in the growth of human colon carcinoma cell in vitro and in vivo.
Top losses	CA14	22399497	CRC	Differentially expressed in colorectal cancer tumors compared to adjacent non-cancerous tissues.
Top losses	CACNA1A	20143136:28781648	sporadic CRC	Down-regulations in colorectal cancer cells.
Top losses	CHST8	16531451	CRC	Differentially expressed in in SW480; a primary tumor cell line; compared to SW620; an isogenic metastatic cell line.
Top losses	CMTM5	17908965	CC	CMTM5 is silenced and methylated in CC cell line HCT116.
Top losses	ENPP6	22399497	CRC	Differentially expressed in colorectal cancer tumors compared to adjacent non-cancerous tissues.
Top losses	ESR2	28681123	CRC	The ER-beta(ESR2) expression was lower in T3/T4 colorectal tumors than in T1/T2 tumors.
Top losses	FAM90A1	22399497	CRC	Differentially expressed in colorectal cancer tumors compared to adjacent non-cancerous tissues.
Top losses	FOXH1	30594391	CRC	FAST1(FOXH1) was significantly associated with CRC progression.
Top losses	GDF9	22399497	CRC	Differentially expressed in colorectal cancer tumors compared to adjacent non-cancerous tissues.
Top losses	GFI1B	22399497	CRC	Differentially expressed in colorectal cancer tumors compared to adjacent non-cancerous tissues.
Top losses	HAP1	22399497	CRC	Differentially expressed in colorectal cancer tumors compared to adjacent non-cancerous tissues.
Top losses	HIST1H2AG	16887128	CC	Altered histone modifications in CC HT29 cells.
Top losses	HIST1H2AI	16887128	CC	Altered histone modifications in CC HT29 cells.
Top losses	HIST1H2AK	16887128	CC	Altered histone modifications in CC HT29 cells.
Top losses	HIST1H2AL	16887128	CC	Altered histone modifications in CC HT29 cells.
Top losses	HIST1H2AM	16887128	CC	Altered histone modifications in CC HT29 cells.
Top losses	KHDRBS2	22399497	CRC	Differentially expressed in colorectal cancer tumors compared to adjacent non-cancerous tissues.
Top losses	MYOC	22399497	CRC	Differentially expressed in colorectal cancer tumors compared to adjacent non-cancerous tissues.
Top losses	P2RY12	22399497	CRC	Differentially expressed in colorectal cancer tumors compared to adjacent non-cancerous tissues.
Top losses	PPP2R2B	21075311	CRC	PPP2R2B; encoding B55b; is the only subunit that is consistently downregulated or silenced in all examined CRC cell lines; but not in the normal colon mucosa samples.
Top losses	PTH1R	22399497	CRC	Differentially expressed in colorectal cancer tumors compared to adjacent non-cancerous tissues.
Top losses	RPL10L	22399497	CRC	Differentially expressed in colorectal cancer tumors compared to adjacent non-cancerous tissues.
Top losses	SCN2B	22399497	CRC	Differentially expressed in colorectal cancer tumors compared to adjacent non-cancerous tissues.
Top losses	SH3GL2	29698419	Breast-colorectal cancer phenotype	Polymorphism associated with breast-colorectal cancer phenotype.
Top losses	SUSD4	23482636	CC	SUSD4 positive tumor-infiltrating cells were detected in CC samples.
Top losses	TAGLN3	29568398	CC	The high expression of TAGLN3 was associated with decreased risk of BRAF mutant CC relapse.
Top losses	TEX11	19914252	CC	Metastasis-associated gene expression profile.
Top losses	TP63	23015401	CRC	p63(TP63) was negatively correlated with peritumoral deposits and positively associated with overall survival and progression-free survival in CRC.
Top losses	TRIM9	22399497	CRC	Differentially expressed in colorectal cancer tumors compared to adjacent non-cancerous tissues.
Top losses	TTR	22399497	CRC	Differentially expressed in colorectal cancer tumors compared to adjacent non-cancerous tissues.
Top losses	TUBB1	27556505	CRC	Upregulated expressed in colorectal cancer tumors compared to adjacent non-cancerous tissues.
Top losses	USP49	29748582	CRC	USP49-knockout mice are more susceptible to colorectal cancer induced by azoxymethane/dextran sulfate sodium (AOM/DSS).
Top losses	ZBTB16	22399497	CRC	Differentially expressed in colorectal cancer tumors compared to adjacent non-cancerous tissues.
Top cancer-specific losses	FAM184A	22399497	CRC	Differentially expressed in colorectal cancer tumors compared to adjacent non-cancerous tissues.
Top cancer-specific losses	FOXH1	22399497	CRC	Differentially expressed in colorectal cancer tumors compared to adjacent non-cancerous tissues.
Top cancer-specific losses	HIST1H2AG	16887128	CC	Altered histone modifications in CC HT29 cells.
Top cancer-specific losses	HIST1H2AI	16887128	CC	Altered histone modifications in CC HT29 cells.
Top cancer-specific losses	HIST1H2AK	16887128	CC	Altered histone modifications in CC HT29 cells.
Top cancer-specific losses	HIST1H2AL	16887128	CC	Altered histone modifications in CC HT29 cells.
Top cancer-specific losses	HIST1H2AM	16887128	CC	Altered histone modifications in CC HT29 cells.
Top cancer-specific losses	PDIA2	22399497	CRC	Differentially expressed in colorectal cancer tumors compared to adjacent non-cancerous tissues.
Top cancer-specific losses	RIMBP3	22399497	CRC	Differentially expressed in colorectal cancer tumors compared to adjacent non-cancerous tissues.
Top cancer-specific losses	RPL10L	22399497	CRC	Differentially expressed in colorectal cancer tumors compared to adjacent non-cancerous tissues.
Top cancer-specific losses	ATP1B2	26835885	CRC	rs1642763 (ATP1B2) were associated with an increased risk of dying in CRC patients who received oxaliplatin.
Top cancer-specific losses	CMYA5	22399497	CRC	Differentially expressed in colorectal cancer tumors compared to adjacent non-cancerous tissues.
Top cancer-specific losses	FBXO27	22399497	CRC	Differentially expressed in colorectal cancer tumors compared to adjacent non-cancerous tissues.
Top cancer-specific losses	HTR3E	24760461	CRC	Polymorphism associated with CRC.
Top cancer-specific losses	ISL2	22399497	CRC	Differentially expressed in colorectal cancer tumors compared to adjacent non-cancerous tissues.
Top cancer-specific losses	RIBC1	22399497	CRC	Differentially expressed in colorectal cancer tumors compared to adjacent non-cancerous tissues.
Top cancer-specific losses	RNF152	30662620	CRC	The expression of RNF152; a ring finger protein; in CRC tissues was significantly reduced compared with adjacent non-cancerous tissue.
Top cancer-specific losses	TLX2	23867710	CRC	Differentially methylated in colorectal cancer samples compared to healthy tissue samples.
SMGs within edgetic gains or losses	ACVR2A	30856244	CRC	The larger colorectal tumors (T3 and T4) were characterized by higher ACVR2A expression compared to smaller tumors (T1 and T2).
SMGs within edgetic gains or losses	AKT1	30387805	CC	The knockdown of AKT1 and AKT2 inhibited cell proliferation and colony growth; by attenuating cell cycle progression and increasing apoptosis in CC cells.
SMGs within edgetic gains or losses	APC	10982779	CRC	APC mutation associated with CRC.
SMGs within edgetic gains or losses	AXIN1	26894286	CRC	Polymorphism associated with CRC.
SMGs within edgetic gains or losses	AXIN2	11752446	CC	Upregulated in SW620 colon cancer cell line.
SMGs within edgetic gains or losses	B2M	22353804	CC	B2M mutation associated with CC
SMGs within edgetic gains or losses	BAX	9020077	CC	BAX mutation associated with CC.
SMGs within edgetic gains or losses	CTNNB1	29156750	CRC	CTNNB1 mutation associated with CRC.
SMGs within edgetic gains or losses	CUX1	22810696	CRC	CUX1 mutation associated with CRC.
SMGs within edgetic gains or losses	EIF3E	25400724	CC	Overexpression of eIF3e is correlated with colon tumor development and poor prognosis
SMGs within edgetic gains or losses	EP300	12385008	CC	EP300 truncating mutations was found in 4 CC cell lines (HCT116; HT29; LIM2405 and LIM2412)
SMGs within edgetic gains or losses	EPHA7	16007213	CRC	EphA7 is down-regulated by hypermethylation in colorectal cancer.
SMGs within edgetic gains or losses	ERBB3	9712416	CRC	Differentially expressed in tumor samples compared to normal samples
SMGs within edgetic gains or losses	FAT3	22399497	CRC	Differentially expressed in colorectal cancer tumors compared to adjacent non-cancerous tissues
SMGs within edgetic gains or losses	FBXW7	19739118	CRC	FBXW7 mRNA expression was significantly lower in tumor tissues than the corresponding normal tissues
SMGs within edgetic gains or losses	GRIN2A	17922030	CRC	The N-methyl-D-aspartate receptor type 2A (GRIN2A) is frequently methylated in human colorectal carcinoma and suppresses cell growth
SMGs within edgetic gains or losses	HIF1A	20363910	CRC	HIF1A overexpression is associated with poor prognosis in a cohort of 731 colorectal cancers
SMGs within edgetic gains or losses	KRAS	20007845	CC	KRAS mutation associated with CC.
SMGs within edgetic gains or losses	LEPROTL1	16531451	CRC	Differentially expressed in SW480 cell line compared to SW620 cell line.
SMGs within edgetic gains or losses	MDM2	27624283	CC	MDM2 promoter SNP55 (rs2870820) affects risk of CC but not breast-; lung-; or prostate cancer.
SMGs within edgetic gains or losses	MLH1	28224663	CRC	Up to 15% of sporadic CRCs caused by hypermethylation of the MLH1 promoter.
SMGs within edgetic gains or losses	MSH2	28537674	CC	MSH2 mRNA and protein expression increased significantly over time (p < 0.05) in patients with CC.
SMGs within edgetic gains or losses	PCBP1	16531451	CRC	Differentially expressed in SW480 cell line compared to SW620 cell line.
SMGs within edgetic gains or losses	PIK3CA	15994075	CRC	In colorectal carcinoma; PIK3CA mutations occur preferentially together with activating KRAS-BRAF mutations (MSI and MSS) while in gastric carcinomas PIK3CA mutations tend to occur as isolated events (MSI).
SMGs within edgetic gains or losses	PIK3R1	18245521	CC	Polymorphism associated with CC.
SMGs within edgetic gains or losses	PTEN	25873394	CC	PTEN inhibits the progression of CC by inhibiting paxillin expression downstream of PI3K/AKT/NF-κappaB pathway.
SMGs within edgetic gains or losses	RSPO2	28600110	CRC	RSPO2 suppresses colorectal cancer metastasis by counteracting the Wnt5a/Fzd7-driven noncanonical Wnt pathway.
SMGs within edgetic gains or losses	SALL4	26617716	CRC	Inhibition of SALL4 suppresses carcinogenesis of colorectal cancer via regulating Gli1 expression.
SMGs within edgetic gains or losses	SFRP4	19730886	CRC	SFRP4 was overexpressed in 16 of 20 CRC samples.
SMGs within edgetic gains or losses	SMAD2	23139211	sporadic CRC	SMAD2 mutation associated with sporadic CRC.
SMGs within edgetic gains or losses	SMAD3	23139211	sporadic CRC	SMAD3 mutation associated with sporadic CRC.
SMGs within edgetic gains or losses	SMAD4	26861460	CC	Reduced expression of SMAD4 Is associated with poor survival in CC.
SMGs within edgetic gains or losses	SRC	24361441	CC	Eighty percent of patients with CC overexpress Src in tumor tissue.
SMGs within edgetic gains or losses	TGFBR2	15256431	CC	in an in vivo model system the loss of Tgfbr2 in the colon epithelium contributes to CC formation by promoting the establishment and progression of AOM-induced colon neoplasms
SMGs within edgetic gains or losses	TGIF1	29575536	CC	Polymorphism associated with CC.
SMGs within edgetic gains or losses	TP53	30562757	CC	High expressions of CUL4A and TP53 in colorectal cancer predict poor survival.
SMGs within edgetic gains or losses	UBR5	29441938	CC	UBR5 was highly expressed in CC not only at mRNA level but also at protein level.
SMGs within edgetic gains or losses	USP44	24837038	CRC	The USP44 CGI was hypermethylated in all CRC cell lines; in most colorectal adenomas (79 of 89; 89%) but rarely in normal mucosa samples (3 of 51; 6%).
SMGs within edgetic gains or losses	ZNRF3	27661107	CRC	RNF43 and ZNRF3 are commonly altered in serrated pathway colorectal tumorigenesis.

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