CAMPS

Welcome to CAMPS2.0

The CAMPS (Computational Analysis of the Membrane Protein Space) database is a resource for the automatic classification of α-helical membrane proteins with at least three transmembrane helices. Together with the classification CAMPS provides numerous links to other databases and membrane protein resources.

This web interface represents the second version of the CAMPS database. The first release can be found here.


Find out more about CAMPS →

CAMPS in a nutshell:
 
•  CAMPS is an automatic approach to the structural classification of α-helical membrane proteins.
•  It is based on sequence clustering and secondary structure prediction.
•  CAMPS approaches three clustering levels: fold, function and modeling distance
 
Statistics:
 
•  Number of sequences: 413,714
•  Number of genomes: 1253 (Archaea: 57, Bacteria: 792, Eukarya: 134, Viruses: 270)
•  Number of SC-clusters (fold level): 1353
•  Number of FH-clusters (function level): 1319
•  Number of MD-clusters (modeling distance level): 7047
 
CAMPS is what you need, if ...
 
•  ...you want a rough organization of the membrane sequence space
•  ...you are searching for membrane protein candidates for protein target selection
•  ...you are studying membrane protein evolution
•  ...you are working on structure-function relationships in membrane proteins
 

Reference:

Neumann S, Hartmann H, Martin-Galiano AJ, Fuchs A, Frishman D. (2012) CAMPS 2.0: exploring the sequence and structure space of prokaryotic, eukaryotic and viral membrane proteins. Proteins, 80(3): 839-857

Neumann S, Fuchs A, Hummel B, Frishman D. Classification of alpha-helical membrane proteins using predicted helix architectures. (submitted)

Linked databases:
CATH
Protein structure classification database
DrugBank
Database of drugs and drug targets
EggNOG
Database of orthologous groups
GPCRDB
Database of G protein-coupled receptors
MPtopo
Database of membrane proteins with experimentally validated transmembrane segments
OMIM
Database of human genes and genetic disorders
OPM
Orientations of proteins in membranes database
PDBTM
Protein Data Bank of Transmembrane Proteins
Pfam
Database of protein families
SCOP
Protein structure classification database
TargetDB
Target registration database
TCDB
Functional and Phylogenetic Classification of Membrane Transport Proteins
VFDB
Virulence factor database
Technische Universität München - Department of Genome Oriented Bioinformatics