Results of ProfCom job # 3069 - 5all :

ProfCom searches for rules - complex functions - that are overrepresented in your gene set of interest (set A) and simultaneously underrepresented in your reference set of genes (Set B). In the following you find the top enriched complex functions along with information about the annotation data used.

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Top enriched complex functions of degree 3

Column explanations can be found below

N Simulation Distribution,P-value Hypergeometric Distribution, P-value SET A statistics SET A size SET B statistics SET B size Category Code Category Name Genes
1 0.02 5.5e-06 8 127 129 17606 ((((GO:0051301) EXCLUDING (GO:0005874))) EXCLUDING (GO:0030054)) ((((cell division ) EXCLUDING (microtubule ))) EXCLUDING (cell junction )) PTTG1 RUVBL1 STK15 SMC4L1 CKS1B MAEA CAPG CDC2
2 0.02 5.5e-06 9 127 174 17606 ((((GO:0007049) AND (GO:0005515))) EXCLUDING (GO:0006355)) ((((cell cycle ) AND (protein binding ))) EXCLUDING (regulation of transcription, DNA-dependent )) PTTG1 RUVBL1 STK15 SMC4L1 CAV1 CKS1B H2AFX CAPG CDC2
3 0.02 6.9e-06 10 127 230 17606 ((((GO:0005198) EXCLUDING (GO:0005923))) EXCLUDING (GO:0007155)) ((((structural molecule activity ) EXCLUDING (tight junction ))) EXCLUDING (cell adhesion )) TUBA1 TUBA2 TUBA3 ACTG2 CAV1 COPB2 KRT6B KRT8 ANXA1 KRT17
4 0.03 6.2e-06 12 127 342 17606 ((((GO:0007049) EXCLUDING (GO:0006355))) EXCLUDING (GO:0005506)) ((((cell cycle ) EXCLUDING (regulation of transcription, DNA-dependent ))) EXCLUDING (iron ion binding )) NBL1 PTTG1 RUVBL1 STK15 SMC4L1 CAV1 CKS1B H2AFX MAEA ANXA1 CAPG CDC2
5 0.03 5.1e-05 8 127 180 17606 ((GO:0005634) AND (((GO:0007049) EXCLUDING (GO:0006355)))) ((nucleus ) AND (((cell cycle ) EXCLUDING (regulation of transcription, DNA-dependent )))) PTTG1 RUVBL1 STK15 SMC4L1 H2AFX MAEA CAPG CDC2
6 0.04 8.4e-09 41 127 2594 17606 ((((GO:0005737) EXCLUDING (GO:0006355))) EXCLUDING (GO:0015031)) ((((cytoplasm ) EXCLUDING (regulation of transcription, DNA-dependent ))) EXCLUDING (protein transport )) PRDX1 PGK1 PTTG1 RUVBL1 SCEL STK24 SMC4L1 SNX6 STRBP SNCG TMOD3 TPM4 VBP1 ADAM9 ARPC4 ARPC5 ACTG2 ALDH1A3 CAPN1 CAV1 CCT5 COPB2 DDEF2 DIA1 ENO1 HAPIP HPGD ISG15 KPNA2 LIPA MAEA MAL2 ANXA1 CAPG LCN2 LGALS3 PSMA7 S100A11 S100P SFN TXNL2
7 0.05 3.3e-05 11 127 343 17606 ((((GO:0005887) EXCLUDING (GO:0004872))) EXCLUDING (GO:0005624)) ((((integral to plasma membrane ) EXCLUDING (receptor activity ))) EXCLUDING (membrane fraction )) B3GNT3 ADAM9 CAV1 HAS3 HLA-DQA1 CAV2 CD9 CEACAM5 DAF FXYD3 MMP14
8 0.06 4.6e-08 38 127 2405 17606 ((((GO:0005737) EXCLUDING (GO:0046872))) EXCLUDING (GO:0015031)) ((((cytoplasm ) EXCLUDING (metal ion binding ))) EXCLUDING (protein transport )) PRDX1 PGK1 PTTG1 RUVBL1 STK24 SMC4L1 SNX6 STRBP SNCG TMOD3 TPM4 VBP1 ARPC4 ARPC5 ACTG2 ALDH1A3 CAPN1 CAV1 CCT5 COPB2 DIA1 ENO1 HAPIP HPGD ISG15 KPNA2 LIPA MAEA MAL2 ANXA1 CAPG LCN2 LGALS3 PSMA7 S100A11 S100P SFN TXNL2
9 0.06 0.00012 8 127 206 17606 ((((GO:0007155) EXCLUDING (GO:0007156))) EXCLUDING (GO:0005737)) ((((cell adhesion ) EXCLUDING (homophilic cell adhesion ))) EXCLUDING (cytoplasm )) CD9 FN ITGA1 ITGA2 ITGA3 LAMC2 TGFBI TSPAN-1
10 0.07 7.3e-05 12 127 449 17606 ((GO:0016020) AND (((GO:0005887) EXCLUDING (GO:0005624)))) ((membrane ) AND (((integral to plasma membrane ) EXCLUDING (membrane fraction )))) B3GNT3 CAV1 HAS3 HLA-DQA1 CAV2 CD9 CEACAM5 DAF ERBB3 FXYD3 MMP14 RAI3
11 0.07 5.7e-05 13 127 511 17606 ((((GO:0005887) EXCLUDING (GO:0006810))) EXCLUDING (GO:0005624)) ((((integral to plasma membrane ) EXCLUDING (transport ))) EXCLUDING (membrane fraction )) B3GNT3 ADAM9 CAV1 HAS3 HLA-DQA1 CAV2 CD9 CEACAM5 DAF ERBB3 FXYD3 MMP14 RAI3
12 0.07 2.2e-08 46 127 3382 17606 ((((GO:0005515) EXCLUDING (GO:0046872))) EXCLUDING (GO:0005739)) ((((protein binding ) EXCLUDING (metal ion binding ))) EXCLUDING (mitochondrion )) NAP1L1 POH1 PTTG1 RUVBL1 SMC4L1 SLC16A1 SNX6 SNCG TUBA1 UBE2L6 XRCC4 ARPC5 ACTG2 CAV1 CKS1B COPB2 ENO1 EVA1 FEN1 FOXM1 H2AFX HAPIP ISG15 ILF2 KPNA2 KRT15 KRT6B KRT8 MAL2 MCM4 CAPG CAV2 CD9 CDC2 ERBB3 ITGA3 KRT17 KRT19 LAMC2 LGALS3 MMP14 PSMA7 SNRPB TGFBI TIMP1 TXNL2
13 0.07 1.1e-05 21 127 1087 17606 ((GO:0005737) AND (((GO:0005515) EXCLUDING (GO:0006355)))) ((cytoplasm ) AND (((protein binding ) EXCLUDING (regulation of transcription, DNA-dependent )))) PTTG1 RUVBL1 SCEL SMC4L1 SNX6 SNCG ADAM9 ARPC5 ACTG2 CAV1 COPB2 DDEF2 ENO1 HAPIP ISG15 KPNA2 MAL2 CAPG LGALS3 PSMA7 TXNL2
14 0.07 0.00017 10 127 348 17606 ((((GO:0005576) EXCLUDING (GO:0005615))) EXCLUDING (GO:0005509)) ((((extracellular region ) EXCLUDING (extracellular space ))) EXCLUDING (calcium ion binding )) ASP AGR2 4 CTSD FN IGFBP3 INHBB LGALS3 SLPI TIMP1
15 0.07 6.5e-08 44 127 3238 17606 ((((GO:0005515) EXCLUDING (GO:0006355))) EXCLUDING (GO:0046872)) ((((protein binding ) EXCLUDING (regulation of transcription, DNA-dependent ))) EXCLUDING (metal ion binding )) NAP1L1 POH1 PTTG1 RUVBL1 SMC4L1 SLC16A1 SNX6 SNCG TUBA1 UBE2L6 XRCC4 ARPC5 ACTG2 CAV1 CKS1B COPB2 ENO1 EVA1 FEN1 H2AFX HAPIP ISG15 ILF2 KPNA2 KRT15 KRT6B KRT8 MAL2 CAPG CAV2 CD9 CDC2 ERBB3 ITGA3 KRT17 KRT19 LAMC2 LGALS3 MMP14 PSMA7 SNRPB TGFBI TIMP1 TXNL2
16 0.09 1.7e-08 49 127 3790 17606 ((((GO:0005515) EXCLUDING (GO:0006355))) EXCLUDING (GO:0006412)) ((((protein binding ) EXCLUDING (regulation of transcription, DNA-dependent ))) EXCLUDING (translation )) NAP1L1 POH1 PTTG1 RUVBL1 SCEL STK15 SMC4L1 SLC16A1 SNX6 SNCG TUBA1 UBE2L6 XRCC4 ADAM9 ARPC5 ACTG2 BUB3 CAV1 CKS1B COPB2 DDEF2 ENO1 EVA1 FEN1 H2AFX HAPIP ISG15 ILF2 KPNA2 KRT15 KRT6B KRT8 MAL2 CAPG CAV2 CD9 CDC2 ERBB3 ITGA3 KRT17 KRT19 LAMC2 LGALS3 MMP14 PSMA7 SNRPB TGFBI TIMP1 TXNL2

Details:
Column "Set A statistics" reports the number of genes from the category in the set A, in brackets the size of the set A is given.
Column "Set B statistics" reports the number of genes from the category in the set B (all other genes from the reference set), in brackets the size of the set B is given.
Column "P value" reports the p value computed by simulation procedure or by hypergeometric distribution.
Column "Category code" reports the category code.
Column "Category name" reports the category name.


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