Results of ProfCom job # 3069 - 5all :

ProfCom searches for rules - complex functions - that are overrepresented in your gene set of interest (set A) and simultaneously underrepresented in your reference set of genes (Set B). In the following you find the top enriched complex functions along with information about the annotation data used.

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Top enriched complex functions of degree 1

Column explanations can be found below

N Simulation Distribution,P-value Hypergeometric Distribution, P-value SET A statistics SET A size SET B statistics SET B size Category Code Category Name Genes
1 0.01 2.5e-05 8 127 162 17606 GO:0051301 cell division PTTG1 RUVBL1 STK15 SMC4L1 CKS1B MAEA CAPG CDC2
2 0.01 4.2e-05 10 127 289 17606 GO:0005198 structural molecule activity TUBA1 TUBA2 TUBA3 ACTG2 CAV1 COPB2 KRT6B KRT8 ANXA1 KRT17
3 0.01 4e-05 12 127 419 17606 GO:0007049 cell cycle NBL1 PTTG1 RUVBL1 STK15 SMC4L1 CAV1 CKS1B H2AFX MAEA ANXA1 CAPG CDC2
4 0.04 1.6e-07 41 127 2935 17606 GO:0005737 cytoplasm PRDX1 PGK1 PTTG1 RUVBL1 SCEL STK24 SMC4L1 SNX6 STRBP SNCG TMOD3 TPM4 VBP1 ADAM9 ARPC4 ARPC5 ACTG2 ALDH1A3 CAPN1 CAV1 CCT5 COPB2 DDEF2 DIA1 ENO1 HAPIP HPGD ISG15 KPNA2 LIPA MAEA MAL2 ANXA1 CAPG LCN2 LGALS3 PSMA7 S100A11 S100P SFN TXNL2
5 0.04 0.00048 7 127 194 17606 GO:0008283 cell proliferation PRDX1 BUB3 CAV1 CKS1B SFN TGFBI TSPAN-1
6 0.04 5.1e-08 51 127 4284 17606 GO:0005515 protein binding NAP1L1 POH1 PTTG1 RUVBL1 SCEL STK15 SMC4L1 SLC16A1 SNX6 SNCG TUBA1 UBE2L6 XRCC4 ADAM9 ARPC5 ACTG2 BUB3 CAV1 CKS1B COPB2 DDEF2 ENO1 EVA1 FEN1 FOXM1 H2AFX HAPIP ISG15 ILF2 KPNA2 KRT15 KRT6B KRT8 MAL2 MCM4 CAPG CAV2 CD9 CDC2 ERBB3 ITGA3 KRT17 KRT19 LAMC2 LGALS3 MMP14 PSMA7 SNRPB TGFBI TIMP1 TXNL2
7 0.06 0.0009 11 127 522 17606 GO:0005576 extracellular region PSG11 ASP AGR2 4 CTSD FN IGFBP3 INHBB LGALS3 SLPI TIMP1
8 0.07 0.0015 9 127 391 17606 GO:0007155 cell adhesion EVA1 CD9 FN ITGA1 ITGA2 ITGA3 LAMC2 TGFBI TSPAN-1
9 0.08 0.00094 13 127 706 17606 GO:0005887 integral to plasma membrane B3GNT3 ADAM9 CAV1 HAS3 HLA-DQA1 CAV2 CD9 CEACAM5 DAF ERBB3 FXYD3 MMP14 RAI3

Details:
Column "Set A statistics" reports the number of genes from the category in the set A, in brackets the size of the set A is given.
Column "Set B statistics" reports the number of genes from the category in the set B (all other genes from the reference set), in brackets the size of the set B is given.
Column "P value" reports the p value computed by simulation procedure or by hypergeometric distribution.
Column "Category code" reports the category code.
Column "Category name" reports the category name.


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