Results of ProfCom job # 8872 - 17u :

ProfCom searches for rules - complex functions - that are overrepresented in your gene set of interest (set A) and simultaneously underrepresented in your reference set of genes (Set B). In the following you find the top enriched complex functions along with information about the annotation data used.

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Top enriched complex functions of degree 3

Column explanations can be found below

N Simulation Distribution,P-value Hypergeometric Distribution, P-value SET A statistics SET A size SET B statistics SET B size Category Code Category Name Genes
1 0.01 3.6e-06 8 46 363 17607 ((((GO:0005509) EXCLUDING (GO:0016020))) EXCLUDING (GO:0005783)) ((((calcium ion binding ) EXCLUDING (membrane ))) EXCLUDING (endoplasmic reticulum )) S100P MMP1 GAS ANXA10 THBS2 PLS1 EFHD2 MRC1
2 0.01 9.5e-06 8 46 418 17607 ((((GO:0005576) EXCLUDING (GO:0016020))) EXCLUDING (GO:0007275)) ((((extracellular region ) EXCLUDING (membrane ))) EXCLUDING (multicellular organismal development )) GAS THBS2 SERPINE1 RNASE1 TFF3 IL6 IL8 CXCL12
3 0.01 1.7e-05 8 46 454 17607 ((((GO:0005509) EXCLUDING (GO:0016021))) EXCLUDING (GO:0007156)) ((((calcium ion binding ) EXCLUDING (integral to membrane ))) EXCLUDING (homophilic cell adhesion )) S100P MMP1 GAS ANXA10 THBS2 PLS1 LDLR EFHD2
4 0.01 2.5e-05 9 46 640 17607 ((((GO:0005509) EXCLUDING (GO:0000166))) EXCLUDING (GO:0007156)) ((((calcium ion binding ) EXCLUDING (nucleotide binding ))) EXCLUDING (homophilic cell adhesion )) S100P MMP1 GAS ANXA10 THBS2 PLS1 LDLR EFHD2 MRC1

Details:
Column "Set A statistics" reports the number of genes from the category in the set A, in brackets the size of the set A is given.
Column "Set B statistics" reports the number of genes from the category in the set B (all other genes from the reference set), in brackets the size of the set B is given.
Column "P value" reports the p value computed by simulation procedure or by hypergeometric distribution.
Column "Category code" reports the category code.
Column "Category name" reports the category name.

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N	Simulation Distribution,P-value	Hypergeometric Distribution, P-value	SET A statistics	SET A size	SET B statistics	SET B size	Category Code	Category Name	Genes
1	0.01	3.6e-06	8	46	363	17607	((((GO:0005509) EXCLUDING (GO:0016020))) EXCLUDING (GO:0005783))	((((calcium ion binding ) EXCLUDING (membrane ))) EXCLUDING (endoplasmic reticulum ))	S100P MMP1 GAS ANXA10 THBS2 PLS1 EFHD2 MRC1
2	0.01	9.5e-06	8	46	418	17607	((((GO:0005576) EXCLUDING (GO:0016020))) EXCLUDING (GO:0007275))	((((extracellular region ) EXCLUDING (membrane ))) EXCLUDING (multicellular organismal development ))	GAS THBS2 SERPINE1 RNASE1 TFF3 IL6 IL8 CXCL12
3	0.01	1.7e-05	8	46	454	17607	((((GO:0005509) EXCLUDING (GO:0016021))) EXCLUDING (GO:0007156))	((((calcium ion binding ) EXCLUDING (integral to membrane ))) EXCLUDING (homophilic cell adhesion ))	S100P MMP1 GAS ANXA10 THBS2 PLS1 LDLR EFHD2
4	0.01	2.5e-05	9	46	640	17607	((((GO:0005509) EXCLUDING (GO:0000166))) EXCLUDING (GO:0007156))	((((calcium ion binding ) EXCLUDING (nucleotide binding ))) EXCLUDING (homophilic cell adhesion ))	S100P MMP1 GAS ANXA10 THBS2 PLS1 LDLR EFHD2 MRC1