Results of ProfCom job # 1138 - 2 :

ProfCom searches for rules - complex functions - that are overrepresented in your gene set of interest (set A) and simultaneously underrepresented in your reference set of genes (Set B). In the following you find the top enriched complex functions along with information about the annotation data used.

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Top enriched complex functions of degree 3

Column explanations can be found below

N Simulation Distribution,P-value Hypergeometric Distribution, P-value SET A statistics SET A size SET B statistics SET B size Category Code Category Name Genes
1 0.01 2.4e-13 9 73 38 17607 ((GO:0007067) AND (((GO:0051301) AND (GO:0005515)))) ((mitosis ) AND (((cell division ) AND (protein binding )))) MAD2L1 CDC2 BUB1B STK15 CCNB2 CCNB1 CDC25B CIT PTTG1
2 0.01 9.2e-16 12 73 73 17607 ((((GO:0051301) AND (GO:0005634))) EXCLUDING (GO:0000775)) ((((cell division ) AND (nucleus ))) EXCLUDING (chromosome, pericentric region )) KNTC1 MAD2L1 CDC2 CCNE2 BUB1B SMC4L1 STK15 ZWINT CCNB2 CCNB1 PTTG1 CNAP1
3 0.01 7.4e-15 11 73 62 17607 ((GO:0005515) AND (((GO:0051301) EXCLUDING (GO:0016020)))) ((protein binding ) AND (((cell division ) EXCLUDING (membrane )))) MAD2L1 CDC2 CCNE2 BUB1B SMC4L1 STK15 CCNB2 CCNB1 CDC25B CIT PTTG1
4 0.01 1.4e-15 12 73 76 17607 ((((GO:0051301) AND (GO:0007067))) EXCLUDING (GO:0005874)) ((((cell division ) AND (mitosis ))) EXCLUDING (microtubule )) KNTC1 MAD2L1 CDC2 BUB1B STK15 CCNB2 CCNB1 CDC25B CIT UBCH10 PTTG1 CNAP1
5 0.01 2.5e-17 15 73 132 17607 ((((GO:0051301) EXCLUDING (GO:0016020))) EXCLUDING (GO:0005525)) ((((cell division ) EXCLUDING (membrane ))) EXCLUDING (GTP binding )) KNTC1 MAD2L1 CDC2 CCNE2 BUB1B SMC4L1 STK15 ZWINT CCNB2 CCNB1 CDC25B CIT UBCH10 PTTG1 CNAP1
6 0.01 1.6e-15 14 73 140 17607 ((GO:0051301) AND (((GO:0007049) EXCLUDING (GO:0005622)))) ((cell division ) AND (((cell cycle ) EXCLUDING (intracellular )))) KNTC1 MAD2L1 CDC2 CCNE2 BUB1B SMC4L1 STK15 ZWINT CCNB2 CCNB1 CIT UBCH10 PTTG1 CNAP1
7 0.01 1.9e-13 11 73 86 17607 ((((GO:0007067) AND (GO:0007049))) EXCLUDING (GO:0008150)) ((((mitosis ) AND (cell cycle ))) EXCLUDING (biological_process )) KNTC1 MAD2L1 CDC2 BUB1B STK15 CCNB2 CCNB1 CIT UBCH10 PTTG1 CNAP1
8 0.01 6.1e-12 9 73 57 17607 ((((GO:0006260) EXCLUDING (GO:0005622))) EXCLUDING (GO:0008270)) ((((DNA replication ) EXCLUDING (intracellular ))) EXCLUDING (zinc ion binding )) FEN1 TK1 TOP2A RFC5 RFC4 RNASEHI MCM7 RPA3 JUNB
9 0.01 3.5e-14 14 73 178 17607 ((((GO:0007049) AND (GO:0005634))) EXCLUDING (GO:0006350)) ((((cell cycle ) AND (nucleus ))) EXCLUDING (transcription )) KNTC1 MAD2L1 CDC2 CCNE2 BUB1B SMC4L1 STK15 ZWINT CCNB2 CCNB1 PTTG1 EP300 CNAP1 TPM3
10 0.01 1.3e-14 15 73 209 17607 ((GO:0005634) AND (((GO:0007049) EXCLUDING (GO:0005622)))) ((nucleus ) AND (((cell cycle ) EXCLUDING (intracellular )))) KNTC1 MAD2L1 CDC2 CCNE2 MCM7 BUB1B SMC4L1 STK15 ZWINT CCNB2 CCNB1 PTTG1 EP300 CNAP1 TPM3
11 0.01 2.6e-15 18 73 338 17607 ((((GO:0007049) EXCLUDING (GO:0016020))) EXCLUDING (GO:0003723)) ((((cell cycle ) EXCLUDING (membrane ))) EXCLUDING (RNA binding )) KNTC1 CDKN3 MAD2L1 CDC2 CCNE2 MCM7 BUB1B SMC4L1 STK15 ZWINT CCNB2 CCNB1 CIT UBCH10 PTTG1 EP300 CNAP1 TPM3
12 0.01 6.5e-11 10 73 112 17607 ((((GO:0000074) EXCLUDING (GO:0006350))) EXCLUDING (GO:0008083)) ((((regulation of progression through cell cycle ) EXCLUDING (transcription ))) EXCLUDING (growth factor activity )) CDC2 MPHOSPH9 CCNE2 CCNB2 TTK CCNB1 CDC25B PPP3CB MYBL2 JUNB
13 0.01 2.2e-13 16 73 314 17607 ((((GO:0007049) EXCLUDING (GO:0003676))) EXCLUDING (GO:0045786)) ((((cell cycle ) EXCLUDING (nucleic acid binding ))) EXCLUDING (negative regulation of progression through cell cycle )) KNTC1 CDKN3 MAD2L1 CDC2 CCNE2 MCM7 SMC4L1 STK15 ZWINT CCNB2 CCNB1 CIT UBCH10 PTTG1 EP300 CNAP1
14 0.01 2.6e-09 9 73 120 17607 ((GO:0000074) EXCLUDING (((GO:0005737) EXCLUDING (GO:0006612)))) ((regulation of progression through cell cycle ) EXCLUDING (((cytoplasm ) EXCLUDING (protein targeting to membrane )))) CDC2 MPHOSPH9 CCNE2 CCNB2 TTK CDC25B PPP3CB MYBL2 JUNB
15 0.01 2.6e-09 9 73 120 17607 ((GO:0000074) EXCLUDING (((GO:0006355) EXCLUDING (GO:0005622)))) ((regulation of progression through cell cycle ) EXCLUDING (((regulation of transcription, DNA-dependent ) EXCLUDING (intracellular )))) CDC2 MPHOSPH9 CCNE2 CCNB2 TTK CCNB1 CDC25B PPP3CB JUNB
16 0.01 5.7e-17 41 73 2888 17607 ((((GO:0005634) EXCLUDING (GO:0005622))) EXCLUDING (GO:0030528)) ((((nucleus ) EXCLUDING (intracellular ))) EXCLUDING (transcription regulator activity )) KNTC1 FEN1 TOP2A RFC5 RFC4 MAD2L1 CDC2 RNASEHI CCNE2 MCM7 BUB1B SMC4L1 STK15 ZWINT CCNB2 RPA3 CCNB1 TMPO ESRRB MSMB SMARCD1 MYBL2 HOXB5 ZFP36 EZH2 SATB1 FOS NR4A1 PTTG1 CTRL EP300 JUNB FOXM1 PROP1 CNAP1 HOXC5 U5-100K CGGBP1 CEBPD FHL1 TPM3
17 0.01 1.6e-16 40 73 2791 17607 ((((GO:0005634) EXCLUDING (GO:0005622))) EXCLUDING (GO:0016020)) ((((nucleus ) EXCLUDING (intracellular ))) EXCLUDING (membrane )) KNTC1 FEN1 TOP2A RFC5 RFC4 MAD2L1 CDC2 RNASEHI CCNE2 MCM7 BUB1B SMC4L1 STK15 ZWINT CCNB2 RPA3 CCNB1 ESRRB MSMB SMARCD1 MYBL2 HOXB5 ZFP36 EZH2 SATB1 FOS NR4A1 PTTG1 CTRL EP300 JUNB FOXM1 PROP1 CNAP1 HOXC5 U5-100K CGGBP1 CEBPD FHL1 TPM3
18 0.01 9.1e-07 9 73 249 17607 ((GO:0005524) AND (((GO:0005634) EXCLUDING (GO:0006350)))) ((ATP binding ) AND (((nucleus ) EXCLUDING (transcription )))) TOP2A RFC5 RFC4 CDC2 BUB1B SMC4L1 STK15 SATB1 U5-100K
19 0.01 5.9e-12 33 73 2529 17607 ((((GO:0005634) EXCLUDING (GO:0006350))) EXCLUDING (GO:0003676)) ((((nucleus ) EXCLUDING (transcription ))) EXCLUDING (nucleic acid binding )) KNTC1 FEN1 TOP2A RFC5 RFC4 MAD2L1 CDC2 RNASEHI CCNE2 BUB1B SMC4L1 STK15 ZWINT CCNB2 RPA3 CCNB1 TMPO MSMB SMARCD1 MYBL2 HOXB5 ZFP36 SATB1 FOS PTTG1 CTRL EP300 JUNB PROP1 CNAP1 HOXC5 FHL1 TPM3
20 0.01 4e-12 34 73 2677 17607 ((((GO:0005634) EXCLUDING (GO:0006350))) EXCLUDING (GO:0030528)) ((((nucleus ) EXCLUDING (transcription ))) EXCLUDING (transcription regulator activity )) KNTC1 FEN1 TOP2A RFC5 RFC4 MAD2L1 CDC2 RNASEHI CCNE2 BUB1B SMC4L1 STK15 ZWINT CCNB2 RPA3 CCNB1 TMPO MSMB SMARCD1 MYBL2 HOXB5 ZFP36 SATB1 FOS PTTG1 CTRL EP300 JUNB PROP1 CNAP1 HOXC5 U5-100K FHL1 TPM3
21 0.01 1.7e-13 40 73 3564 17607 ((((GO:0005634) EXCLUDING (GO:0003676))) EXCLUDING (GO:0000122)) ((((nucleus ) EXCLUDING (nucleic acid binding ))) EXCLUDING (negative regulation of transcription from RNA polymerase II promoter )) KNTC1 FEN1 TOP2A RFC5 RFC4 MAD2L1 CDC2 RNASEHI CCNE2 MCM7 BUB1B SMC4L1 STK15 ZWINT CCNB2 RPA3 CCNB1 TMPO ESRRB MSMB SMARCD1 MYBL2 HOXB5 ZFP36 EZH2 SATB1 FOS NR4A1 PTTG1 CTRL EP300 JUNB FOXM1 PROP1 CNAP1 HOXC5 CGGBP1 CEBPD FHL1 TPM3
22 0.01 1.7e-08 18 73 939 17607 ((((GO:0005524) EXCLUDING (GO:0000287))) EXCLUDING (GO:0016021)) ((((ATP binding ) EXCLUDING (magnesium ion binding ))) EXCLUDING (integral to membrane )) TK1 TOP2A RFC5 RFC4 KNSL2 CDC2 MCM7 BUB1B SMC4L1 STK15 TTK STK11 KIAA0135 CSNK1G2 CIT SATB1 U5-100K ACTA2
23 0.01 5.4e-08 16 73 779 17607 ((GO:0000166) AND (((GO:0005524) EXCLUDING (GO:0016020)))) ((nucleotide binding ) AND (((ATP binding ) EXCLUDING (membrane )))) TK1 TOP2A RFC5 RFC4 KNSL2 CDC2 MCM7 BUB1B SMC4L1 STK15 TTK KIAA0135 CSNK1G2 CIT U5-100K ACTA2
24 0.01 1.3e-06 10 73 342 17607 ((((GO:0043565) EXCLUDING (GO:0005622))) EXCLUDING (GO:0005783)) ((((sequence-specific DNA binding ) EXCLUDING (intracellular ))) EXCLUDING (endoplasmic reticulum )) KNTC1 ESRRB HOXB5 FOS NR4A1 JUNB FOXM1 PROP1 HOXC5 CEBPD
25 0.01 6.5e-11 33 73 2804 17607 ((GO:0005634) EXCLUDING (((GO:0008270) EXCLUDING (GO:0016020)))) ((nucleus ) EXCLUDING (((zinc ion binding ) EXCLUDING (membrane )))) KNTC1 FEN1 TOP2A RFC5 RFC4 CDC2 RNASEHI CCNE2 MCM7 BUB1B SMC4L1 ZWINT CCNB2 RPA3 CCNB1 TMPO MSMB SMARCD1 MYBL2 HOXB5 EZH2 FOS PTTG1 CTRL JUNB FOXM1 PROP1 CNAP1 HOXC5 U5-100K CGGBP1 CEBPD TPM3
26 0.01 3.3e-07 15 73 779 17607 ((((GO:0000166) AND (GO:0005524))) EXCLUDING (GO:0016787)) ((((nucleotide binding ) AND (ATP binding ))) EXCLUDING (hydrolase activity )) TK1 TOP2A RFC5 RFC4 KNSL2 CDC2 MCM7 BUB1B SMC4L1 STK15 TTK KIAA0135 CSNK1G2 CIT ACTA2
27 0.01 2e-06 13 73 665 17607 ((((GO:0003700) EXCLUDING (GO:0000122))) EXCLUDING (GO:0000166)) ((((transcription factor activity ) EXCLUDING (negative regulation of transcription from RNA polymerase II promoter ))) EXCLUDING (nucleotide binding )) KNTC1 ESRRB MYBL2 HOXB5 FOS NR4A1 PTTG1 EP300 JUNB FOXM1 PROP1 HOXC5 CEBPD
28 0.01 9.7e-07 17 73 1121 17607 ((((GO:0000166) EXCLUDING (GO:0003723))) EXCLUDING (GO:0007264)) ((((nucleotide binding ) EXCLUDING (RNA binding ))) EXCLUDING (small GTPase mediated signal transduction )) TK1 TOP2A RFC5 RFC4 MAD2L1 KNSL2 CDC2 MCM7 BUB1B SMC4L1 STK15 TTK KIAA0135 CSNK1G2 CIT U5-100K ACTA2
29 0.01 4.2e-05 9 73 414 17607 ((((GO:0016740) AND (GO:0000166))) EXCLUDING (GO:0005887)) ((((transferase activity ) AND (nucleotide binding ))) EXCLUDING (integral to plasma membrane )) TK1 MAD2L1 CDC2 BUB1B STK15 TTK KIAA0135 CSNK1G2 CIT
30 0.05 0.00012 11 73 730 17607 ((((GO:0016740) EXCLUDING (GO:0000287))) EXCLUDING (GO:0008415)) ((((transferase activity ) EXCLUDING (magnesium ion binding ))) EXCLUDING (acyltransferase activity )) TK1 MAD2L1 CDC2 BUB1B STK15 TTK KIAA0135 CSNK1G2 CIT EP300 TPM3

Details:
Column "Set A statistics" reports the number of genes from the category in the set A, in brackets the size of the set A is given.
Column "Set B statistics" reports the number of genes from the category in the set B (all other genes from the reference set), in brackets the size of the set B is given.
Column "P value" reports the p value computed by simulation procedure or by hypergeometric distribution.
Column "Category code" reports the category code.
Column "Category name" reports the category name.


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