Results of ProfCom job # 1138 - 2 :

ProfCom searches for rules - complex functions - that are overrepresented in your gene set of interest (set A) and simultaneously underrepresented in your reference set of genes (Set B). In the following you find the top enriched complex functions along with information about the annotation data used.

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Top enriched complex functions of degree 1

Column explanations can be found below

N Simulation Distribution,P-value Hypergeometric Distribution, P-value SET A statistics SET A size SET B statistics SET B size Category Code Category Name Genes
1 0.01 4.1e-16 15 73 162 17607 GO:0051301 cell division KNTC1 MAD2L1 CDC2 CCNE2 BUB1B SMC4L1 STK15 ZWINT CCNB2 CCNB1 CDC25B CIT UBCH10 PTTG1 CNAP1
2 0.01 7.8e-14 12 73 110 17607 GO:0007067 mitosis KNTC1 MAD2L1 CDC2 BUB1B STK15 CCNB2 CCNB1 CDC25B CIT UBCH10 PTTG1 CNAP1
3 0.01 1.1e-10 9 73 81 17607 GO:0006260 DNA replication FEN1 TK1 TOP2A RFC5 RFC4 RNASEHI MCM7 RPA3 JUNB
4 0.01 8.2e-14 18 73 419 17607 GO:0007049 cell cycle KNTC1 CDKN3 MAD2L1 CDC2 CCNE2 MCM7 BUB1B SMC4L1 STK15 ZWINT CCNB2 CCNB1 CIT UBCH10 PTTG1 EP300 CNAP1 TPM3
5 0.01 1.3e-09 10 73 156 17607 GO:0000074 regulation of progression through cell cycle CDC2 MPHOSPH9 CCNE2 CCNB2 TTK CCNB1 CDC25B PPP3CB MYBL2 JUNB
6 0.01 1.7e-12 41 73 4129 17607 GO:0005634 nucleus KNTC1 FEN1 TOP2A RFC5 RFC4 MAD2L1 CDC2 RNASEHI CCNE2 MCM7 BUB1B SMC4L1 STK15 ZWINT CCNB2 RPA3 CCNB1 TMPO ESRRB MSMB SMARCD1 MYBL2 HOXB5 ZFP36 EZH2 SATB1 FOS NR4A1 PTTG1 CTRL EP300 JUNB FOXM1 PROP1 CNAP1 HOXC5 U5-100K CGGBP1 CEBPD FHL1 TPM3
7 0.01 5e-06 10 73 401 17607 GO:0043565 sequence-specific DNA binding KNTC1 ESRRB HOXB5 FOS NR4A1 JUNB FOXM1 PROP1 HOXC5 CEBPD
8 0.01 3.7e-07 18 73 1176 17607 GO:0005524 ATP binding TK1 TOP2A RFC5 RFC4 KNSL2 CDC2 MCM7 BUB1B SMC4L1 STK15 TTK STK11 KIAA0135 CSNK1G2 CIT SATB1 U5-100K ACTA2
9 0.01 2.9e-05 8 73 298 17607 GO:0004674 protein serine/threonine kinase activity BUB1B STK15 TTK STK11 KIAA0135 CSNK1G2 CIT TPM3
10 0.01 4.5e-06 13 73 721 17607 GO:0003700 transcription factor activity KNTC1 ESRRB MYBL2 HOXB5 FOS NR4A1 PTTG1 EP300 JUNB FOXM1 PROP1 HOXC5 CEBPD
11 0.01 0.00027 8 73 421 17607 GO:0006468 protein amino acid phosphorylation CDC2 BUB1B STK15 TTK STK11 KIAA0135 CSNK1G2 CIT
12 0.02 3.2e-05 17 73 1504 17607 GO:0000166 nucleotide binding TK1 TOP2A RFC5 RFC4 MAD2L1 KNSL2 CDC2 MCM7 BUB1B SMC4L1 STK15 TTK KIAA0135 CSNK1G2 CIT U5-100K ACTA2
13 0.09 0.0013 11 73 997 17607 GO:0016740 transferase activity TK1 MAD2L1 CDC2 BUB1B STK15 TTK KIAA0135 CSNK1G2 CIT EP300 TPM3

Details:
Column "Set A statistics" reports the number of genes from the category in the set A, in brackets the size of the set A is given.
Column "Set B statistics" reports the number of genes from the category in the set B (all other genes from the reference set), in brackets the size of the set B is given.
Column "P value" reports the p value computed by simulation procedure or by hypergeometric distribution.
Column "Category code" reports the category code.
Column "Category name" reports the category name.

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N	Simulation Distribution,P-value	Hypergeometric Distribution, P-value	SET A statistics	SET A size	SET B statistics	SET B size	Category Code	Category Name	Genes
1	0.01	4.1e-16	15	73	162	17607	GO:0051301	cell division	KNTC1 MAD2L1 CDC2 CCNE2 BUB1B SMC4L1 STK15 ZWINT CCNB2 CCNB1 CDC25B CIT UBCH10 PTTG1 CNAP1
2	0.01	7.8e-14	12	73	110	17607	GO:0007067	mitosis	KNTC1 MAD2L1 CDC2 BUB1B STK15 CCNB2 CCNB1 CDC25B CIT UBCH10 PTTG1 CNAP1
3	0.01	1.1e-10	9	73	81	17607	GO:0006260	DNA replication	FEN1 TK1 TOP2A RFC5 RFC4 RNASEHI MCM7 RPA3 JUNB
4	0.01	8.2e-14	18	73	419	17607	GO:0007049	cell cycle	KNTC1 CDKN3 MAD2L1 CDC2 CCNE2 MCM7 BUB1B SMC4L1 STK15 ZWINT CCNB2 CCNB1 CIT UBCH10 PTTG1 EP300 CNAP1 TPM3
5	0.01	1.3e-09	10	73	156	17607	GO:0000074	regulation of progression through cell cycle	CDC2 MPHOSPH9 CCNE2 CCNB2 TTK CCNB1 CDC25B PPP3CB MYBL2 JUNB
6	0.01	1.7e-12	41	73	4129	17607	GO:0005634	nucleus	KNTC1 FEN1 TOP2A RFC5 RFC4 MAD2L1 CDC2 RNASEHI CCNE2 MCM7 BUB1B SMC4L1 STK15 ZWINT CCNB2 RPA3 CCNB1 TMPO ESRRB MSMB SMARCD1 MYBL2 HOXB5 ZFP36 EZH2 SATB1 FOS NR4A1 PTTG1 CTRL EP300 JUNB FOXM1 PROP1 CNAP1 HOXC5 U5-100K CGGBP1 CEBPD FHL1 TPM3
7	0.01	5e-06	10	73	401	17607	GO:0043565	sequence-specific DNA binding	KNTC1 ESRRB HOXB5 FOS NR4A1 JUNB FOXM1 PROP1 HOXC5 CEBPD
8	0.01	3.7e-07	18	73	1176	17607	GO:0005524	ATP binding	TK1 TOP2A RFC5 RFC4 KNSL2 CDC2 MCM7 BUB1B SMC4L1 STK15 TTK STK11 KIAA0135 CSNK1G2 CIT SATB1 U5-100K ACTA2
9	0.01	2.9e-05	8	73	298	17607	GO:0004674	protein serine/threonine kinase activity	BUB1B STK15 TTK STK11 KIAA0135 CSNK1G2 CIT TPM3
10	0.01	4.5e-06	13	73	721	17607	GO:0003700	transcription factor activity	KNTC1 ESRRB MYBL2 HOXB5 FOS NR4A1 PTTG1 EP300 JUNB FOXM1 PROP1 HOXC5 CEBPD
11	0.01	0.00027	8	73	421	17607	GO:0006468	protein amino acid phosphorylation	CDC2 BUB1B STK15 TTK STK11 KIAA0135 CSNK1G2 CIT
12	0.02	3.2e-05	17	73	1504	17607	GO:0000166	nucleotide binding	TK1 TOP2A RFC5 RFC4 MAD2L1 KNSL2 CDC2 MCM7 BUB1B SMC4L1 STK15 TTK KIAA0135 CSNK1G2 CIT U5-100K ACTA2
13	0.09	0.0013	11	73	997	17607	GO:0016740	transferase activity	TK1 MAD2L1 CDC2 BUB1B STK15 TTK KIAA0135 CSNK1G2 CIT EP300 TPM3