Results of ProfCom job # 3243 - A116 :

ProfCom searches for rules - complex functions - that are overrepresented in your gene set of interest (set A) and simultaneously underrepresented in your reference set of genes (Set B). In the following you find the top enriched complex functions along with information about the annotation data used.

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Top enriched complex functions of degree 3

Column explanations can be found below

N Simulation Distribution,P-value Hypergeometric Distribution, P-value SET A statistics SET A size SET B statistics SET B size Category Code Category Name Genes
1 0.01 2.7e-10 7 72 34 17607 ((((GO:0005201) EXCLUDING (GO:0007275))) EXCLUDING (GO:0007601)) ((((extracellular matrix structural constituent ) EXCLUDING (multicellular organismal development ))) EXCLUDING (visual perception )) COL4A1 LAMB1 COL4A2 LAMC1 MAGP2 COMP TFPI2
2 0.01 3.7e-10 11 72 187 17607 ((((GO:0005615) EXCLUDING (GO:0008083))) EXCLUDING (GO:0006955)) ((((extracellular space ) EXCLUDING (growth factor activity ))) EXCLUDING (immune response )) ORM1 IGFBP1 RBP4 PTHLH LBP IL6 STC1 MAGP2 MYOC PVR TCN2
3 0.01 9.2e-08 7 72 86 17607 ((GO:0005576) AND (((GO:0005615) EXCLUDING (GO:0006955)))) ((extracellular region ) AND (((extracellular space ) EXCLUDING (immune response )))) ORM1 IGFBP1 RBP4 PTHLH LBP IL6 STC1
4 0.01 5.6e-11 15 72 396 17607 ((((GO:0005576) EXCLUDING (GO:0006955))) EXCLUDING (GO:0006508)) ((((extracellular region ) EXCLUDING (immune response ))) EXCLUDING (proteolysis )) ORM1 IGFBP1 IGFBP3 RBP4 DEFB1 COL4A1 PTHLH LBP IL6 SLPI STC1 COMP TFPI2 CDA ERBB2
5 0.01 6.5e-08 10 72 245 17607 ((((GO:0007155) EXCLUDING (GO:0007156))) EXCLUDING (GO:0005198)) ((((cell adhesion ) EXCLUDING (homophilic cell adhesion ))) EXCLUDING (structural molecule activity )) E48 MCAM NID2 LAMB1 LAMC1 COMP CSPG2 PVR PTPRM MIG2
6 0.01 5.4e-07 8 72 170 17607 ((GO:0005515) AND (((GO:0007155) EXCLUDING (GO:0007156)))) ((protein binding ) AND (((cell adhesion ) EXCLUDING (homophilic cell adhesion )))) E48 MCAM LAMB1 LAMC1 COMP PVR PTPRM MIG2
7 0.01 2.4e-07 9 72 213 17607 ((((GO:0007155) EXCLUDING (GO:0016021))) EXCLUDING (GO:0045941)) ((((cell adhesion ) EXCLUDING (integral to membrane ))) EXCLUDING (positive regulation of transcription )) E48 MCAM NID2 LAMB1 LAMC1 COMP CSPG2 PTPRM MIG2
8 0.02 0.00012 9 72 485 17607 ((((GO:0016020) AND (GO:0005515))) EXCLUDING (GO:0016021)) ((((membrane ) AND (protein binding ))) EXCLUDING (integral to membrane )) E48 MAL PIG7 CYP1B1 NDRG1 PSCDBP HCLS1 PTPRM MIG2

Details:
Column "Set A statistics" reports the number of genes from the category in the set A, in brackets the size of the set A is given.
Column "Set B statistics" reports the number of genes from the category in the set B (all other genes from the reference set), in brackets the size of the set B is given.
Column "P value" reports the p value computed by simulation procedure or by hypergeometric distribution.
Column "Category code" reports the category code.
Column "Category name" reports the category name.


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