Results of ProfCom job # 3243 - A116 :

ProfCom searches for rules - complex functions - that are overrepresented in your gene set of interest (set A) and simultaneously underrepresented in your reference set of genes (Set B). In the following you find the top enriched complex functions along with information about the annotation data used.

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Top enriched complex functions of degree 1

Column explanations can be found below

N Simulation Distribution,P-value Hypergeometric Distribution, P-value SET A statistics SET A size SET B statistics SET B size Category Code Category Name Genes
1 0.01 2.3e-09 7 72 48 17607 GO:0005201 extracellular matrix structural constituent COL4A1 LAMB1 COL4A2 LAMC1 MAGP2 COMP TFPI2
2 0.01 2.5e-08 11 72 288 17607 GO:0005615 extracellular space ORM1 IGFBP1 RBP4 PTHLH LBP IL6 STC1 MAGP2 MYOC PVR TCN2
3 0.01 2e-09 15 72 522 17607 GO:0005576 extracellular region ORM1 IGFBP1 IGFBP3 RBP4 DEFB1 COL4A1 PTHLH LBP IL6 SLPI STC1 COMP TFPI2 CDA ERBB2
4 0.01 1e-05 6 72 118 17607 GO:0008285 negative regulation of cell proliferation GPC3 PTHLH IL6 TOB1 TIMP2 WARS

5 0.01 3.6e-06 10 72 391 17607 GO:0007155 cell adhesion E48 MCAM NID2 LAMB1 LAMC1 COMP CSPG2 PVR PTPRM MIG2

6 0.01 9.4e-05 6 72 180 17607 GO:0005578 proteinaceous extracellular matrix GPC3 LAMB1 MAGP2 COMP TFPI2 CSPG2
7 0.09 7.6e-05 23 72 2935 17607 GO:0005737 cytoplasm MAL CRYM CRYAB COL4A1 PTHLH NNMT COL4A2 PRX2 CST6 TOB1 GLRX NDRG1 FOXO1A ANXA4 PVR PSCDBP HCLS1 PLS3 PDXK WARS EEF1A2 MIG2 ERBB2

Details:
Column "Set A statistics" reports the number of genes from the category in the set A, in brackets the size of the set A is given.
Column "Set B statistics" reports the number of genes from the category in the set B (all other genes from the reference set), in brackets the size of the set B is given.
Column "P value" reports the p value computed by simulation procedure or by hypergeometric distribution.
Column "Category code" reports the category code.
Column "Category name" reports the category name.

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N	Simulation Distribution,P-value	Hypergeometric Distribution, P-value	SET A statistics	SET A size	SET B statistics	SET B size	Category Code	Category Name	Genes
1	0.01	2.3e-09	7	72	48	17607	GO:0005201	extracellular matrix structural constituent	COL4A1 LAMB1 COL4A2 LAMC1 MAGP2 COMP TFPI2
2	0.01	2.5e-08	11	72	288	17607	GO:0005615	extracellular space	ORM1 IGFBP1 RBP4 PTHLH LBP IL6 STC1 MAGP2 MYOC PVR TCN2
3	0.01	2e-09	15	72	522	17607	GO:0005576	extracellular region	ORM1 IGFBP1 IGFBP3 RBP4 DEFB1 COL4A1 PTHLH LBP IL6 SLPI STC1 COMP TFPI2 CDA ERBB2
4	0.01	1e-05	6	72	118	17607	GO:0008285	negative regulation of cell proliferation	GPC3 PTHLH IL6 TOB1 TIMP2 WARS
5	0.01	3.6e-06	10	72	391	17607	GO:0007155	cell adhesion	E48 MCAM NID2 LAMB1 LAMC1 COMP CSPG2 PVR PTPRM MIG2
6	0.01	9.4e-05	6	72	180	17607	GO:0005578	proteinaceous extracellular matrix	GPC3 LAMB1 MAGP2 COMP TFPI2 CSPG2
7	0.09	7.6e-05	23	72	2935	17607	GO:0005737	cytoplasm	MAL CRYM CRYAB COL4A1 PTHLH NNMT COL4A2 PRX2 CST6 TOB1 GLRX NDRG1 FOXO1A ANXA4 PVR PSCDBP HCLS1 PLS3 PDXK WARS EEF1A2 MIG2 ERBB2