Results of ProfCom job #
3243 - A116
:
ProfCom searches for rules - complex functions - that are overrepresented in your gene set of interest (set A) and simultaneously underrepresented in your reference set of genes (Set B). In the following you find the top enriched complex functions along with information about the annotation data used.
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Top enriched complex functions of degree 1
Column explanations can be found below
N | Simulation Distribution,P-value | Hypergeometric Distribution, P-value | SET A statistics | SET A size | SET B statistics | SET B size | Category Code | Category Name | Genes |
1 | 0.01 | 2.3e-09 | 7 | 72 | 48 | 17607 | GO:0005201 | extracellular matrix structural constituent | COL4A1 LAMB1 COL4A2 LAMC1 MAGP2 COMP TFPI2 |
2 | 0.01 | 2.5e-08 | 11 | 72 | 288 | 17607 | GO:0005615 | extracellular space | ORM1 IGFBP1 RBP4 PTHLH LBP IL6 STC1 MAGP2 MYOC PVR TCN2 |
3 | 0.01 | 2e-09 | 15 | 72 | 522 | 17607 | GO:0005576 | extracellular region | ORM1 IGFBP1 IGFBP3 RBP4 DEFB1 COL4A1 PTHLH LBP IL6 SLPI STC1 COMP TFPI2 CDA ERBB2 |
4 | 0.01 | 1e-05 | 6 | 72 | 118 | 17607 | GO:0008285 | negative regulation of cell proliferation | GPC3 PTHLH IL6 TOB1 TIMP2 WARS |
5 | 0.01 | 3.6e-06 | 10 | 72 | 391 | 17607 | GO:0007155 | cell adhesion | E48 MCAM NID2 LAMB1 LAMC1 COMP CSPG2 PVR PTPRM MIG2 |
6 | 0.01 | 9.4e-05 | 6 | 72 | 180 | 17607 | GO:0005578 | proteinaceous extracellular matrix | GPC3 LAMB1 MAGP2 COMP TFPI2 CSPG2 |
7 | 0.09 | 7.6e-05 | 23 | 72 | 2935 | 17607 | GO:0005737 | cytoplasm | MAL CRYM CRYAB COL4A1 PTHLH NNMT COL4A2 PRX2 CST6 TOB1 GLRX NDRG1 FOXO1A ANXA4 PVR PSCDBP HCLS1 PLS3 PDXK WARS EEF1A2 MIG2 ERBB2 |
Details:
Column "Set A statistics" reports the number of genes from the category in the
set A, in brackets the size of the set A is given.
Column "Set B statistics" reports the number of genes from the category in the
set B (all other genes from the reference set), in brackets the size of the
set B is given.
Column "P value" reports the p value computed by simulation procedure or by
hypergeometric distribution.
Column "Category code" reports the category
code.
Column "Category name" reports the category
name.
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