EdgeExplorer

Welcome to the website of cancer-promoting proteins (oncoproteins) frequently involved in the rewiring of protein-protein interaction networks (edgetic perturbations) in cancer. This site is a resource to promote the discovery and biological annotation of proteins affecting tumorigenesis by altering protein-protein interactions (PPI) in cancer. Briefly, we integrated three datasets; gene expression data from The Cancer Genome Atlas (TCGA), PPI data from BioGRID, and patient survival data form SurvExpress, to reveal oncoproteins at the network level.
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Here, you can click on a cancer type and be redirected to the list of proteins significantly involved in edgetic perturbations at both the cancer-type and subtype levels.

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Overall patient survival Analysis

A majority of the proteins involved in significant egdetic perturbations affect overal patient survival in cancer and are prognostic. Genes/Proteins able to predict prognosis in cancer are vital as cancer biomarkers since they are often linked to tumor progression,can help to accelerate cancer diagnosis and aid in therapeutic decision making.